Europeans and Asians need different doses for same condition
Dietary and lifestyle differences could possibly explain why South Asians and Europeans require different doses of drugs to treat similar conditions, according to Vidya Perera, final year pharmacy doctoral student at the University of Sydney.
Perera found that people from South Asia could manage with lower drug doses because of lower levels of CYP1A2, which is an enzyme that metabolizes drugs.
From in.news.yahoo.com:
Vegetables such as cabbage, cauliflower and broccoli are known to increase levels of CYP1A2,’ according to a Sydney statement.
‘The lower levels of CYP1A2 in South Asians, however, appears to be due to the common practice of cooking these vegetables, using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme,’ explained Perera.
‘This is the first study to look at CYP1A2 activity in South Asians. Understanding the correct dose of a medicine is crucial to achieving beneficial results and avoiding adverse drug reactions,’ she said.
The research was presented by Perera at the AusBiotech 2011 in Australia.
Tags: drug reactions, lifestyle






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